Age-period-cohort analysis of global, regional, and national trends in laryngeal Cancer among older adults, 1990-2021: insights from the 2021 global burden of disease study.

ABSTRACT:

Background

Laryngeal cancer poses a significant health burden among older adults, with varying incidence, mortality, and disability-adjusted life years (DALYs) across regions. These disparities highlight the need for targeted interventions and tailored healthcare policies.

Objectives

To analyze global, regional, and national trends in laryngeal cancer incidence, mortality, and DALYs among older adults from 1990 to 2021 using age-period-cohort modeling and to assess the impact of demographic factors on disease burden across socio-developmental index (SDI) regions.

Materials and methods

Using the 2021 Global Burden of Diseases (GBD) database, trends in age-standardized incidence rates (ASIR), age-standardized mortality rates (ASMR), and age-standardized DALYs rates (ASD

SUBMITTER: Sun Z 

PROVIDER: S-EPMC11983630 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature