Pan-cancer analysis reveals MTTP as a prognostic and immunotherapeutic biomarker in human tumors.

ABSTRACT:

Introduction

Microsomal triglyceride transfer protein (MTTP) is an essential lipid transfer protein for the synthesis and secretion of very low density lipoprotein (VLDL) in hepatocytes and chylomicrons (CM) in intestinal cells. Further researches have revealed that MTTP exerted its functions in a variety of tissues beyond the liver and intestine, including the heart, neural tissues and antigen-presenting cells. Dysregulation of MTTP expression can lead to many diseases, such as lipid metabolism disorders, insulin resistance and cardiovascular diseases. Despite its importance, research on MTTP in cancer is limited, with no comprehensive pan-cancer studies available.

Methods

MTTP expression was explored with the TIMER 2.0 and Sangerbox databases. The pathological stages and s

SUBMITTER: Wang W 

PROVIDER: S-EPMC11983653 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature