Protective role of oleic acid against palmitic acid-induced pancreatic fibrosis.

ABSTRACT:

Background

Obesity has been associated with several pancreatic disorders and is an important risk factor for pancreatic cancer. Nevertheless, the role of lipids in the early steps of carcinogenesis is unknown. Although we previously identified two types of pancreatic fatty infiltration with different lipid compositions that were associated with precancerous lesions and fibrosis, their mechanisms of action have not been clarified.

Methods

We hypothesized that saturated palmitic acid and mono-unsaturated oleic acid (OA and PA) could play diverse roles in the activation of pancreatic stellate cells (PSCs) during the genesis of pancreatic fibrosis and the promotion of precancerous lesions. This study explored the lipotoxic effect of OA and PA on PSCs and exocrine pancreatic tiss

SUBMITTER: Frendi S 

PROVIDER: S-EPMC11983757 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature