Long-term trajectories of apolipoprotein A1 and major adverse cardiovascular events and mortality in a community cohort.

ABSTRACT:

Background

Apolipoprotein A1 (ApoA1) is a major component of high-density lipoprotein cholesterol and plays a critical role in reverse cholesterol transport. Dynamic changes in ApoA1 levels may be associated with major adverse cardiovascular events. This study aimed to evaluate the impact of ApoA1 trajectories over three early assessments.

Methods

Participants in the Chin-Shan Community Cardiovascular Cohort with dyslipidemia and receiving three early ApoA1 assessments were enrolled. Group-based multivariate trajectory modeling was used to classify participants into distinct trajectories after multivariable adjustment. The follow-up duration was from April 1990 to August 2022, and the long-term outcomes of major adverse cardiovascular events (MACE) and death outcomes were ev

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11983767 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature