Influence of race, ethnicity, and sex on the performance of epigenetic predictors of phenotypic traits.

ABSTRACT:

Background

DNA methylation-based predictors of phenotypic traits including leukocyte proportions, smoking activity, biological aging, and circulating levels of plasma proteins are widely used as biomarkers in public health research. However, limited racial and ethnic diversity of research participants is an ongoing issue for epigenetics research, and the potential downstream impacts of limited diversity in training samples on the performance of epigenetic predictors remains poorly understood. We examined the performance of epigenetic predictors of chronological age (also known as epigenetic clocks), telomere length, cell proportions, and plasma proteins within a diverse sample of adult NHANES participants during the 1999-2000 and 2001-2002 survey cycles, both overall and stratified

SUBMITTER: Khodasevich D 

PROVIDER: S-EPMC11983795 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature