Molecular characterization of early-stage lung adenocarcinoma presenting as subsolid nodules in a real-life European cohort.

ABSTRACT:

Objectives

Subsolid nodules emerged as frequent radiological variants of lung adenocarcinoma. Radiological features including solid-component prevalence and larger tumour dimensions prompt tumoral invasiveness guiding prognosis and management. Thus, we aimed to clarify the molecular grounds that dictate these radiological appearances and clinical behaviour in a real-life European-cohort. Additionally, following the growing interest toward targeted-therapies in early-stage diseases, we aimed to present real-life epidemiological data of actionable mutations in these patients.

Methods

In this retrospective single-centre study, targeted next-generation sequencing was performed continuatively in all the resected subsolid lung adenocarcinomas in the period between May 2016 and Dec

SUBMITTER: Taje R 

PROVIDER: S-EPMC11983824 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature