Putative function and prognostic molecular marker of mast cells in colorectal cancer.

ABSTRACT:

Background

The increased demand for markers for colorectal cancer (CRC) highlights the importance of investigating immune cells involved in CRC progression. This study aims to dissect the mast cells in CRC, characterize the role of mast cells in CRC development, coordinate molecular communication between mast cells and malignant cells, and construct and validate a prognostic classification model based on mast cell markers.

Methods

Single-cell transcriptome data of CRC patients were extracted from GSE146771 for cell classification and annotation. The malignant cells were identified by copykat and the communication between mast cells and malignant cells was analyzed by CellChat. Least absolute shrinkage and selection operator (LASSO) regression analysis and Cox regression anal

SUBMITTER: Guo J 

PROVIDER: S-EPMC11983841 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature