Development and validation of a prediction model for the risk of citrate accumulation in critically ill patients with citrate anticoagulation for continuous renal replacement therapy: a retrospective cohort study based on MIMIC-IV database.

ABSTRACT:

Background

Acute kidney injury (AKI) is a common clinical syndrome, especially in the intensive care unit (ICU), with an incidence of more than 50% and in-hospital mortality of 30%. Continuous renal replacement therapy (CRRT) is an important supportive treatment for patients with AKI (Patel in Trauma Surg Acute Care Open e001381, 2024). Citrate is the preferred anticoagulant for critically ill patients requiring CRRT. Unfortunately, such patients may be confronted with citrate accumulation during citrate anticoagulation.

Methods

The MIMIC-IV2.2 database was used to extract data of patients undergoing CRRT who opted for citrate anticoagulation during ICU admission, including 883 critically ill patients. These 883 patients were randomized into training (n = 618) and Internal v

SUBMITTER: Hu ZQ 

PROVIDER: S-EPMC11983910 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature