Exploring METRNL as a novel biomarker in sepsis: diagnostic potential and secretion mechanism.

ABSTRACT:

Background

Sepsis is a life-threatening condition with a high mortality rate in intensive care unit (ICU). However, rapid and accurate diagnostic criteria are still lacking. This pilot study explored the role of METRNL as a novel biomarker for sepsis by focusing on its diagnostic potential and rapid secretion mechanism.

Methods

METRNL levels were measured in cell and animal models of sepsis. Serum samples from 107 sepsis patients and 95 non-septic controls in ICU were collected. Diagnostic performance of METRNL, Procalcitonin (PCT) and C-reactive protein (CRP) were assessed using ROC analysis. Endothelial cell-specific Metrnl gene knockout mice (EC-Metrnl^-/- mice) were used to identify the source of METRNL secretion. Chemical inhibitors and RNA interference were u

SUBMITTER: Xu TY 

PROVIDER: S-EPMC11983927 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature