Genome phylogenetic analysis of Brucella melitensis in Northwest China.

ABSTRACT: Brucellosis poses a severe threat to public health in Northwest China; however, the genome phylogeny and transmission pattern of Brucella melitensis from sheep and yaks in this region remain unclear. In this study, bacteriology, conventional biototyping, and whole-genome single-nucleotide polymorphism (WGS-SNP) were applied to depict the phylogenetic profiles of strains from Northwest China. A total of 46 Brucella strains were identified as B. melitensis bv. 3, which was isolated from at least three animal (livestock and wildlife) hosts, implying that B. melitensis infection is prevalent in the Northwest and suggesting that host diversity provides an optimal niche for the spread and maintenance of B. melitensis in this region. WGS-SNP analysis divided the 46 B. melitensis strains into four

SUBMITTER: Cao X 

PROVIDER: S-EPMC11983976 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature