Association between serum α-Klotho levels and mortality in US adults with osteoporosis.

ABSTRACT:

Background

Klotho, a protein known for its significant involvement in the aging process and age-related diseases, has been demonstrated to be inextricably linked to osteoporosis. Nevertheless, the relationship between serum Klotho levels and mortality risk among individuals with osteoporosis has not been definitively established. Therefore, the purpose of the current research is to examine the potential relationship between serum Klotho levels and mortality risk in individuals aged 40 and above with osteoporosis.

Methods

The current study included adults aged 40 years and older diagnosed with osteoporosis from the National Health and Nutrition Examination Survey. Osteoporosis diagnosis was based on a history of osteoporosis or bone mineral density. Moreover, Cox proportional

SUBMITTER: Tang Y 

PROVIDER: S-EPMC11984054 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature