Resveratrol attenuates the CoCl₂-induced hypoxia damage by regulation of lysine β-hydroxybutyrylation in PC12 cells.

ABSTRACT:

Background

Stroke is a cerebrovascular disease that is the main cause of death and disability worldwide. Hypoxia is a major factor that causes neuronal damage and even cellular death. However, the mechanism and therapeutic drugs for hypoxia are not completely understood.

Methods

In this study, PC12 cells (a rat adrenal pheochromocytoma cell line) were exposed to Cobalt chloride (CoCl₂) to induce hypoxia. Using this cell model, the impacts of hypoxia on cell viability, proliferation, reactive oxygen species (ROS), and the levels of lysine β-hydroxybutyrylation (Kbhb) and the inflammatory signaling factor P65 were examined. In addition, we explored the ability of resveratrol (RES) to alleviate CoCl₂-induced hypoxia damage.

Results

RES attenuated Co

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11984057 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature