Chronic Infection With Gastric Helicobacters Induces Hepatic Lesions in Mice.

ABSTRACT:

Background

Helicobacter pylori infection is one of the most prevalent chronic bacterial infections worldwide. This bacillus colonizes the human stomach lifelong, where it induces chronic gastritis, evolving in some cases to gastro-duodenal ulcers, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. H. pylori infection has also been associated with extragastric diseases, and clinical data have suggested a role in liver pathogenesis. This retrospective study evaluated the consequences of chronic infection with gastric Helicobacters on liver pathogenesis in a mouse experimental model.

Materials and methods

C57BL6 mice were infected with either H. felis (n = 12) or five human and mouse-adapted strains of H. pylori (n = 77) for one year. Uninfected mice were u

SUBMITTER: Seeneevassen L 

PROVIDER: S-EPMC11984071 | biostudies-literature | 2025 Mar-Apr

REPOSITORIES: biostudies-literature