The organophotocatalytic trifluoromethylation of 6-azauracils.

ABSTRACT: An efficient, cost-effective, and metal-free photocatalytic trifluoromethylation of 6-azauracils has been developed using Langlois reagent (CF₃SO₂Na) under ambient air. The present protocol, which utilizes an inexpensive CF₃ reagent and an organophotocatalyst, provides a convenient way to prepare trifluoromethylated azauracil derivatives with a variety of functional groups. The experimental results suggest a radical mechanistic pathway for this methodology.

SUBMITTER: Das KK 

PROVIDER: S-EPMC11984196 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature