Fospropofol disodium versus Propofol for deep sedation in critically ill patients: a randomized pilot study.

ABSTRACT:

Background

Fospropofol disodium is comparable to propofol in maintaining mild-to-moderate sedation for mechanically ventilated patients in intensive care unit (ICU). However, its efficacy for deep sedation remains unclear. Therefore, we conducted a randomized-controlled trial comparing the efficacy and safety of fospropofol disodium with propofol for deep sedation of mechanically ventilated patients in ICU.

Methods

In this randomized pilot study, critically ill adult patients requiring deep sedation were randomized to receive fospropofol disodium or propofol. The study drug was titrated to maintain a Richmond Agitation-Sedation Scale score (RASS) of-5 or-4. Narcotrend Index (NI) value was monitored during the whole study period. The primary outcome was the percentage of time

SUBMITTER: Gao X 

PROVIDER: S-EPMC11984281 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature