Association Between Circulating Cytokines and Endometriosis: A Mendelian Randomization Study.

ABSTRACT: Existing evidence shows the importance of circulating cytokines in studying female reproductive system dysfunction. Endometriosis (EM) is thought to be associated with multiple immune cytokines, but its causality has not been proven. Utilising Genome-Wide Association Study (GWAS) data, we performed Mendelian randomisation (MR) to assess causality between 41 cytokines and EM. Positive Single Nucleotide Polymorphisms (SNPs) were annotated via Multi-marker Analysis of GenoMic Annotation (MAGMA) and intersected with EM-associated genes from Weighted Gene Co-expression Network Analysis (WGCNA). Shared genes underwent single-gene Gene Set Enrichment Analysis (GSEA). The association of shared genes with endometriosis was validated by the quantitative Real-Time Polymerase Chain Reaction (qRT-PCR)

SUBMITTER: Xu X 

PROVIDER: S-EPMC11984317 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature