Accelerated aging associated with cancer characteristics and treatments among breast cancer survivors.

ABSTRACT: Breast cancer (BC) survivors may experience accelerated aging due to detrimental effects of BC and/or its treatments. Our study aims to evaluate Phenotypic Age Acceleration (PAA), a biological age measure, among BC patients and assess its associations with cancer characteristics and treatments. In this study including 1264 BC patients (age 54.7±11.7) and 429 cancer-free controls (age 49.9±12.4), we evaluated the differences in PAA (ΔPAA) by BC characteristics and treatments at multiple time points using linear mixed models. Overall, BC survivors had a higher PAA than controls at diagnosis (ΔPAA=3.73, p<0.001), 1-year (ΔPAA=1.68, p=0.001), and 10-year (ΔPAA=1.16, p=0.03) post-diagnosis. At 10-year post-diagnosis, stage III/IV (vs 0), intermediate- and high- (vs low-) gr

SUBMITTER: Wang C 

PROVIDER: S-EPMC11984420 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature