Facilitators and Barriers to Increasing Equity in Cystic Fibrosis Newborn Screening Algorithms.

ABSTRACT:

Background

Newborn screening (NBS) for cystic fibrosis (CF) was universally implemented in the United States in 2010 to improve disease outcomes. Despite universal screening, disparities in outcomes currently exist between people with CF (PwCF) with Black/African, Asian, Indigenous, and Latino/Hispanic ancestry in comparison to PwCF of European ancestry. This is in part because CFTR panels used for newborn screening are often based on variants common in European ancestries leading to higher rates of false negatives for PwCF from minoritized racial and ethnic groups.

Methods

This study investigated how states evaluate and update their CFNBS algorithms through semi-structured interviews with professionals from four states with ethnically diverse populations and one national co

SUBMITTER: Madden K 

PROVIDER: S-EPMC11984462 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature