A planning approach for online adaptive proton therapy to cope with cone beam computed tomography inaccuracies.

ABSTRACT:

Background and purpose

In online-adaptive proton therapy planning based on cone beam computed tomography (CBCT), CT number errors can pose challenges. We propose an approach for coping with CT number uncertainties by increasing range robustness settings (RRS) in online-adaptive planning. This was compared to our trigger-based offline (TB-Offline) adaptive approach, and to daily replanning using in-room CT-on-rails (CTOR).

Material and methods

For 23 head-and-neck cancer patients, a CTOR and CBCT were acquired in a single fraction. CTOR contours were copied rigidly onto the CBCT. CBCT-based plans were generated with 3, 6, 8, 10, and 12 % RRS, each with 1 mm setup-RS, followed by a forward dose calculation on the reference CTOR. This was compared to dose distributions from our

SUBMITTER: Oud M 

PROVIDER: S-EPMC11984568 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature