ST3GAL1 regulates cancer cell migration through crosstalk between EGFR and neuropilin-1 signaling.

ABSTRACT: Metastasis is a major cause of cancer-related morbidity and mortality. The overexpression of the sialyltransferase ST3GAL1 in breast cancer correlates with metastasis. However, the molecular mechanisms underlying the effect of ST3GAL1 on cell movement are poorly understood. We identified neuropilin-1/NRP1 as a substrate for ST3GAL1. Gene expression analysis revealed that recurrence-free survival (p = 0.0046) and distant metastasis-free survival (p = 0.0003) were significantly shorter in the ST3GAL1^HighNRP1^High cohort than in the both-low subgroup. We demonstrated that the ST3GAL1-mediated sialylation of NRP1 results in increased binding affinity toward EGFR at the molecular level. At the cellular level, ST3GAL1 silencing impaired cell migration and wound healing abili

SUBMITTER: Fan TC 

PROVIDER: S-EPMC11984587 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature