Phenotypic upregulation of hexocylceramides and ether-linked phosphocholines as markers of human extreme longevity.

ABSTRACT: Centenarians and their relatives possess a notable survival advantage, with higher longevity and reduced susceptibility to major age-related diseases. To date, characteristic omics profiles of centenarians have been described, demonstrating that these individuals with exceptional longevity regulate their metabolism to adapt and incorporate more resilient biomolecules into their cells. Among these adaptations, the lipidomic profile stands out. However, it has not yet been determined whether this lipidomic profile is specific to centenarians or is the consequence of extreme longevity genetics and is also present in centenarians' offspring. This distinction is crucial for defining potential therapeutic targets that could help delay the aging process and associated pathologies. We applied mass

SUBMITTER: Fernandez-Bernal A 

PROVIDER: S-EPMC11984674 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature