Unlocking the Promise of Antitumor Hyperthermia-Immunotherapy with Spiky Surface Topology.

ABSTRACT: Uveal melanoma (UM) is the most prevalent primary intraocular malignant tumor in adults with high mortality rate. Recently, immunotherapy has shown great success in other tumors, however, its therapeutic effect in UM is unsatisfactory, possibly due to the insufficient immune cell infiltration and low immunogenicity of UM. Thus, an efficient therapeutic strategy to reverse the immunosuppressive tumor microenvironment is required. Herein, a PD-L1 modified hierarchical structure consisting of a magnetic Fe₃O₄ core and spiky silica shell (MNP@Spiky/PD-L1) is developed to reverse the immunosuppressive tumor microenvironment and trigger powerful antitumor immune responses. The MNP@Spiky can induce enhanced immunogenic cell death as well as physical activation of innate immu

SUBMITTER: Yang M 

PROVIDER: S-EPMC11984835 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature