Advances in individualization of systemic treatment for locoregionally advanced nasopharyngeal carcinoma: a systematic review.

ABSTRACT:

Background

The optimal treatment strategy (radiotherapy with induction, concurrent or adjuvant chemotherapy) for patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC) remains to be addressed. Identifying biomarkers related to precise prognostic risk stratification and treatment benefits gained have been explored in recent years.

Methods

We carried out a systematic review of the published literature covering these topics. Of 3732 references screened, 26 articles were found eligible for inclusion.

Results

Regarding the issue of treatment pathway in LA-NPC, induction chemotherapy is usually preferred over adjuvant chemotherapy. It is paramount to stress patient selection to identify those cases at high risk of relapse requiring systemic intensification.

SUBMITTER: Blanchard P 

PROVIDER: S-EPMC11985003 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature