Albumin nanoassembly bi-directionally manipulated ferroptosis in tumor and CD8⁺ T cells for triple-negative breast cancer therapy.

ABSTRACT: Ferroptosis can serve as a potent strategy for regulating cell death via lipid peroxidation and the imbalance of the antioxidant system resulting from iron accumulation in triple-negative breast cancer (TNBC) therapy. However, the ferroptosis accompanied with down-regulation of glutathione peroxidase 4 (GPX4) lead to CD36-mediated tumor-infiltrating CD8⁺ T cells uptaking fatty acids, resulting in the negative action on immunotherapeutic efficacy. Herein, the albumin nanoparticles, abbreviated as LHS NPs, were designed by co-assembly of hemin, linoleic acid-cystamine, and a CD36 inhibitor sulfosuccinimide oleate, to bi-directionally manipulated ferroptosis in tumor and CD8⁺ T cells for TNBC therapy. LHS NPs exerted more efficient reactive oxygen species generation, glu

SUBMITTER: Yang T 

PROVIDER: S-EPMC11985007 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature