Optimizing Long-term Cardiovascular Risk Stratification: Integrating Biomarkers into the Very High-Risk ASCVD Definition in Asian Patients.

ABSTRACT:

Background

The 2018 American Heart Association/American College of Cardiology (AHA/ACC) cholesterol guideline defines very high-risk (VHR) atherosclerotic cardiovascular disease (ASCVD) patients to guide intensive lipid-lowering therapy.

Objectives

This study sought to evaluate VHR's effectiveness in assessing cardiovascular (CV) risk in an Asian population and examine the predictive value of additional biomarkers for improving risk stratification.

Methods

26,752 ASCVD patients were prospectively enrolled at Fuwai Hospital (2017-2018). VHR was defined as multiple major ASCVD events or one major event with multiple high-risk conditions. The primary outcome was a composite of 3-year CV events, including cardiovascular mortality, myocardial infarction, stroke, and corona

SUBMITTER: Cheng J 

PROVIDER: S-EPMC11985017 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature