Oral microbiome composition is associated with depressive symptoms during pregnancy.

ABSTRACT:

Background

Oral microbiome dysbiosis has been linked to systemic disease with an underlying inflammatory etiology. However, the possible association of the oral microbiome in antenatal depression has received little attention.

Methods

Participants were pregnant women in the PREDICT prenatal cohort study (n = 400) who provided saliva during pregnancy. Using 16S rRNA sequencing, we determined the association between composition of the salivary microbiome and a continuous measure of depressive symptoms (Center for Epidemiological Studies-Depression Scale (CES-D): 0-60) as well as clinically significant depressive symptoms during pregnancy (CES-D score> 16, n = 46) compared with women without clinically significant symptoms (n = 327).

Results

CES-D scores were associated

SUBMITTER: Agranyoni O 

PROVIDER: S-EPMC11985130 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature