Incidence and associated factors with atrial fibrillation in patients with transthyretin amyloidosis cardiomyopathy: Insights from the multicenter REACT-SP registry.

ABSTRACT:

Introduction

Atrial fibrillation (AF) presents a treatment challenge in patients with amyloidosis cardiomyopathy, particularly in transthyretin amyloidosis cardiomyopathy (ATTR-CM). Identifying factors associated with AF is important for early diagnosis and intervention.

Purpose

This study aims to identify factors linked to AF in ATTR-CM patients.

Methods

The REACT registry, a retrospective, multicenter cohort study, enrolled patients with TTR mutation or wild type. ATTR-CM diagnosis was based on echocardiography and pyrophosphate scintigraphy, with some cases confirmed by biopsy. Binary logistic regression and multivariate analysis were used, with ROC curve analysis determining optimal cutoff points for continuous variables.

Results

The study included 273 pati

SUBMITTER: Romero CE 

PROVIDER: S-EPMC11985137 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature