Amur linden honey and its principal polyphenols alleviate obesity and regulate gut microbiota in high-fat diet-induced mice.

ABSTRACT: Obesity has emerged as a critical global health challenge in recent decades, driving increased scientific interest in honey as a sugar alternative. Despite its perceived nutritional benefits, the inherent high fructose-glucose ratio in honey continues to raise concerns regarding metabolic implications for overweight individuals. In this study, Amur linden honey (LH) was evaluated as a low-glycemic-index (GI) dietary intervention, demonstrating significant anti-obesity effects through murine model. Subsequently, nine principal polyphenols (PC) were identified by metabolomics and proven anti-obesity activity in cellular assays, suggesting their potential role in mediating the biological effects of LH. Notably, the anti-obesity effects of LH were more pronounced as compared to the equivalent

SUBMITTER: Chen Z 

PROVIDER: S-EPMC11985147 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature