Situational analysis of antibiotic prescriptions in Kenyan neonatal units for antimicrobial stewardship: a retrospective longitudinal study.

ABSTRACT:

Background

High antibiotic use in neonatal units may drive antimicrobial resistance and cause harm including mortality. We used data from 22 Kenyan neonatal units to (1) describe the proportion with antibiotic prescriptions at admission; (2) assess the predictors of non-first line antibiotic prescription; (3) estimate antibiotic use, and (4) explore postadmission antibiotic switching.

Methods

Retrospective longitudinal study from 1st September 2020 to 31st October 2023. Antibiotics were classified as first line (penicillin plus gentamicin only), third generation cephalosporins (ceftazidime or ceftriaxone) or others. The proportion of antibiotic prescriptions were computed, and a multilevel logistic regression model used to analyse predictors of non-first line prescription. A

SUBMITTER: Aluvaala J 

PROVIDER: S-EPMC11985152 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature