Arsenic enhances cervical cancer cell radiosensitivity by suppressing the DNA damage repair pathway.

ABSTRACT:

Background

Concurrent chemoradiotherapy (CCRT) is a primary treatment for cervical cancer (CC) and combines chemotherapy and radiation therapy to target cancer cells effectively. However, despite its benefits, it also involves a high risk of recurrence and metastasis, partly due to the resistance of some cancer cells to the treatment. Additionally, CCRT can cause various treatment-related adverse reactions, such as gastrointestinal issues, bone marrow suppression, and skin reactions, which can negatively impact patients' quality of life. Therefore, there is a compelling need to develop more effective treatment strategies that can improve the outcomes of CCRT while minimizing its side effects. This study aimed to investigate the radiosensitizing effects of arsenic trioxide (ATO) on

SUBMITTER: Gao X 

PROVIDER: S-EPMC11985179 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature