Feasibility and patient reported tolerance of cryotherapy with Cooral mouth cooling device in patients undergoing radiation therapy (CooRay): a pilot study.

ABSTRACT:

Background

Radiation-induced oral mucositis (RIOM) is a major side-effect of (chemo)radiation (CRT) of patients with head and neck cancer (HNC). This study tries to establish a novel cryotherapy (CyT) method using a mouth care device (MCD; Cooral^®, BrainCool AB, Lund, Sweden) to prevent RIOM.

Methods

Patients were non-randomly assigned to use the MCD after every radiotherapy session for 30-60 minutes. Subjects were asked to answer daily questionnaires assessing tolerability of the intervention. Mucositis was assessed at baseline, once weekly and at weeks 1/3/6 after CRT. The primary endpoint was patient tolerance, defined by the time the MCD was used and the patients' perception. Secondary outcomes were the degree (CTCAE v5.0) and duration of RIOM.

Results

SUBMITTER: Bunea A 

PROVIDER: S-EPMC11985184 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature