Causal associations between atrial fibrillation and esophageal cancer: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Previous studies indicated that atrial fibrillation (AF) patients had a significantly higher esophageal cancer (EC) risk. However, influencing by confounding factors, the causal effect is uncertain. In this study, we aimed to validate the causal relationship between AF and EC by Mendelian randomization (MR) analysis.

Methods

An observational analysis was conducted using the data from the National Health and Nutrition Examination Survey (NHANES) and UK Biobank. Then a two-sample MR method was employed to assess the causal effect of AF on EC. The exposure of AF was collected from publicly available genome-wide association studies (GWASs). Meanwhile, the EC outcome data were derived from the UK Biobank and the FinnGen consortium. A set of 108 single-nucleotide polymo

SUBMITTER: Lei J 

PROVIDER: S-EPMC11985194 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature