Comprehensive analysis of molecular characteristics between primary and breast-derived metastatic ovarian cancer.

ABSTRACT:

Background

The molecular basis for the disparities between primary ovarian cancer (POC) and ovarian cancer secondary to breast cancer (OCSTBC) remains poorly understood. This study aimed to explore the different characteristics between them through genomic analysis.

Methods

We performed differentially expressed genes (DEGs) analysis between POC (n=96) and OCSTBC (n=44) groups with transcriptome data and revealed the enriched biological pathways with Kyoto Encyclopedia of Genes and Genomes (KEGG) and Hallmark gene sets between these two groups. Then, the Microenvironment Cell Populations (MCP)-counter and Cell-type Identification by Estimating Relative Subsets of RNA Transcript (CIBERSORT) algorithms were applied to evaluate the immune infiltration in tumor microenvironment (

SUBMITTER: Long J 

PROVIDER: S-EPMC11985203 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature