Small peritoneal macrophages are accelerators of peritoneal metastasis of colorectal cancer.

ABSTRACT:

Background

The peritoneal cavity (PerC) constitutes a distinct anatomical compartment that harbors various subpopulations of peritoneal macrophages. However, there remains a significant gap in our understanding of the functions of these macrophage subpopulations in the context of peritoneal metastasis of colorectal cancer (PM-CRC) and their roles in the tumor progression process. This investigation seeks to analyze the characteristics of large peritoneal macrophages (LPMs) and small peritoneal macrophages (SPMs), in the context of PM-CRC.

Methods

A murine model of PM-CRC was developed through the intraperitoneal administration of the MC38 colorectal cancer cell line into C57BL/6 mice. Peritoneal effusions were subsequently collected at various time points post-injection and

SUBMITTER: Yang W 

PROVIDER: S-EPMC11985204 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature