Identification of novel neutrophil-extracellular-traps-related genes as biomarkers for breast cancer prognosis and immunotherapy.

ABSTRACT:

Background

Breast cancer (BC) ranks as one of the most prevalent malignancies among women globally. This study aimed to explore the involvement of neutrophil extracellular traps (NETs)-related genes (NETRGs) in BC pathogenesis, highlighting the critical role of NETs.

Methods

Differentially expressed NETRGs (DE-NETRGs) were identified by intersecting BC vs. control differentially expressed genes (DEGs) with the NETRG gene set from The Cancer Genome Atlas breast cancer (TCGA-BRCA) and GSE42568 datasets. Functional analysis elucidated their biological roles. Prognostic biomarkers were selected using least absolute shrinkage and selection operator (LASSO) and Cox regression, generating a predictive model, of which its prognostic predictive ability was evaluated through th

SUBMITTER: Huang Z 

PROVIDER: S-EPMC11985209 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature