A gene signature associated with cellular senescence serves as an important prognostic indicator in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a lethal tumor. Predicting the prognosis of HCC remains challenging. Cellular senescence, which is one of the hallmarks of cancer, and its related prognostic-gene signature can provide critical information for clinical decision making. Our objective was to investigate the role of cellular senescence in HCC.

Methods

The RNA sequencing data and clinical information of HCC patients from The Cancer Genome Atlas (TCGA) database were obtained. The HCC subtypes and a senescence score model were established to predict the prognosis of HCC.

Results

In this study, patients from TCGA-HCC dataset were stratified into low- and high-risk groups based on cellular senescence-related genes. The analysis of the various subtypes revealed that

SUBMITTER: Yan Y 

PROVIDER: S-EPMC11985214 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature