Case Report: Intestinal metastasis from <i>ALK</i>-rearranged pulmonary pleomorphic carcinomas mimicking inflammatory myofibroblastic tumors.

ABSTRACT: Lung carcinomas usually spread to the liver, lungs, pleura, pericardium, adrenal glands, brain, and bones. Anaplastic lymphoma kinase gene (ALK) fusion occurs in approximately 5% of non-small cell lung cancer (NSCLC) cases and most frequently in adenocarcinoma. Here, we report a rare case of intestinal metastasis originating from pulmonary pleomorphic carcinoma in a 49-year-old male heavy smoker. At the local hospital, the patient was initially considered to have an ALK-positive intestinal tumor, leading to a differential diagnosis of inflammatory myofibroblastic tumor (IMT). Due to the tumor's peculiar morphology (including epithelioid and spindle cell components), pathologists of the local hospital sent slides of the case to our hospital for further consultation. Immunohistochemic

SUBMITTER: Shi C 

PROVIDER: S-EPMC11985424 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature