Evaluating the efficacy of subthreshold micropulse laser combined with anti-VEGF drugs in the treatment of diabetic macular edema: a systematic review and meta-analysis.

ABSTRACT:

Objective

To compare the clinical efficacy of subthreshold micropulse laser (SML) combined with anti-VEGF drugs versus anti-VEGF drugs monotherapy for diabetic macular edema (DME) through a meta-analysis.

Methods

We systematically reviewed relevant literature from electronic databases and extracted key outcomes, including best corrected visual acuity (BCVA)-comprising ETDRS and LogMAR measures, central macular thickness (CMT), annual frequency of anti-VEGF injections, annual SML applications, and associated complications for both treatment groups at postoperative intervals of 3, 6, 9, and 12 months.

Results

A total of 13 relevant studies were included in this review, including 405 eyes in the experimental group (SML combined with anti-VEGF drugs intravitreal injection

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC11985442 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature