Hyaluronic acid modified chuanxiong oil liposomes as a novel therapeutic agent for photoaging prevention.

ABSTRACT: The gradual increase in ultraviolet B (UVB) health hazards to human skin, coupled with the irritation associated with existing sunscreen products, underscores the critical need for the development of natural sunscreens to combat UVB-induced photoaging. Chuanxiong oil (CXO) and hyaluronic acid (HA) possess excellent antioxidant and anti-apoptotic properties, which are closely linked to the mechanisms of photoaging. In this study, a composite nano-system (HA-CXO-Lip) comprising chuanxiong oil (CXO) and hyaluronic acid (HA) was initially fabricated. Subsequently, both in vitro HaCaT cell models and in vivo murine photoaging models were established to systematically evaluate the therapeutic efficacy and mechanistic actions of HA-CXO-Lip against photoaging under controlled experimental conditio

SUBMITTER: He X 

PROVIDER: S-EPMC11985960 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature