Respiratory modulations of cortical excitability and interictal spike timing in focal epilepsy: a case report.

ABSTRACT:

Background

Brain activity in focal epilepsy is marked by a pronounced excitation-inhibition (E:I) imbalance and interictal epileptiform discharges (IEDs) observed in periods between recurrent seizures. As a marker of E:I balance, aperiodic neural activity and its underlying 1/f characteristic reflect the dynamic interplay of excitatory and inhibitory currents. Recent studies have independently assessed 1/f changes both in epilepsy and in the context of body-brain interactions in neurotypical individuals where the respiratory rhythm has emerged as a potential modulator of excitability states in the brain.

Methods

Here, we investigate respiration phase-locked modulations of E:I balance and their involvement in the timing of spike discharges in a case report of a 25 year-old fo

SUBMITTER: Kluger DS 

PROVIDER: S-EPMC11985961 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature