Dose-dependent dual effects of HDAC inhibitors on glial inflammatory response.

ABSTRACT: Neuroinflammation is defined as a process that includes cellular responses designed to protect the central nervous system from external influences, and it initiates in cases of extreme deviations from homeostasis. While it serves a protective role, excessive immune activation can lead to the release of neurotoxic factors, worsening disease progression. Histone deacetylases (HDACs) have been shown to modulate the expression of inflammatory genes by remodeling chromatin through the process of histone deacetylation. HDAC inhibitors (HDACi) alter histone acetylation and affect the transcription of genes involved in inflammatory pathways, making them promising therapeutic tools for the modulation of a variety of inflammatory diseases. However, their use is limited due to non-specific targeting

SUBMITTER: Mancino S 

PROVIDER: S-EPMC11986048 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature