NHS-Galleri trial: Enriched enrolment approaches and sociodemographic characteristics of enrolled participants.

ABSTRACT:

Background/aims

Certain sociodemographic groups are routinely underrepresented in clinical trials, limiting generalisability. Here, we describe the extent to which enriched enrolment approaches yielded a diverse trial population enriched for older age in a randomised controlled trial of a blood-based multi-cancer early detection test (NCT05611632).

Methods

Participants aged 50-77 years were recruited from eight Cancer Alliance regions in England. Most were identified and invited from centralised health service lists; a dynamic invitation algorithm was used to target those in older and more deprived groups. Others were invited by their general practice surgery (GP-based Participant Identification Centres in selected regions); towards the end of recruitment, specifically Asian

SUBMITTER: Swanton C 

PROVIDER: S-EPMC11986080 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature