The rat mammary gland undergoes dynamic transcriptomic and lipidomic modifications from pre-puberty to adulthood.

ABSTRACT: Mammary gland development is a complex process involving dynamic interaction between the epithelial and stromal components at different critical stages, particularly around puberty. While epithelial tissue changes are well-documented, stromal mechanisms are less understood. To address this gap, this study employed histology, lipidomic, and transcriptomic analyses to investigate molecular and cellular dynamics in the mammary gland during pre-puberty (Post Natal Day (PND21)), peri-puberty (PND46), and adulthood (PND90) in rats. The epithelial area was significantly smaller at PND21 than at PND46 and PND90, with a higher complexity at PND21 compared to PND46. Significant differences in adipocyte number and size were observed between PND21, PND46, and PND90. Transcriptomic analysis revealed th

SUBMITTER: Tovar-Parra D 

PROVIDER: S-EPMC11986145 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature