Aquaporin 9 downregulation in KRAS^G12V colorectal cancer and associated with increased proliferation and decreased apoptosis in cancer cells.

ABSTRACT: Patients with colorectal cancer (CRC) carrying KRAS mutations face a challenging prognosis, especially due to their reduced response to EGFR inhibitor therapies. Despite the use of drugs targeting the KRAS^G12C mutation, the KRAS^G12V mutation is more common in CRC, and unfortunately, there are currently no effective targeted treatments for it. Our study shows that patients harboring KRAS^G12V mutation often have larger tumors, increased lymph node metastasis, elevated EGFR expression, and a tendency for right-sided colon tumors. This indicates distinct clinical and pathological traits in CRC patients with KRAS^G12V. Cellular studies reveal increased proliferation and decreased cell apoptosis in KRAS^G12V CRC cells. Bioinformatics analysis

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11986171 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature