Ferritin outperforms other biomarkers in predicting bone marrow iron stores in patients with hematologic disorders.

ABSTRACT:

Abstract

Although iron-deficiency anemia is common, interpreting iron laboratory test results can be challenging in patients with comorbidities. We aimed to study the accuracy of common iron biomarkers compared with bone marrow iron staining in a large retrospective data set of patients with hematologic disorders. We collected from 6610 patients (median age, 66 years) results of iron staining, with their concurrent ferritin, transferrin saturation, soluble transferrin receptor, transferrin, hemoglobin, and mean red blood cell volume results from Helsinki University Hospital electronic health records. In receiver operating characteristics analysis, ferritin had the highest area under the curve (AUC) with 88% (95% confidence interval [CI], 86-90) for females and 89% (95% CI, 87-91) f

SUBMITTER: Lahtiharju T 

PROVIDER: S-EPMC11986213 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature