Trial eligibility, treatment patterns, and outcome for venetoclax-based therapy in AML: a prospective cohort study.

ABSTRACT:

Abstract

Venetoclax plus hypomethylating agents are considered standard of care for patients with acute myeloid leukemia (AML) judged ineligible for intensive chemotherapy (IC). Real-world studies complement clinical trials, because patterns of patient selection, treatment exposure, and postremission management may vary. This prospective observational multicenter study included 209 newly diagnosed IC-ineligible patients with a median age 75 years (interquartile range, 71-81 years). A high proportion of patients had secondary AML (53.7%), adverse-risk disease (35.3%), and complex karyotype (15.5%). At a median follow-up of 22.5 months (range, 0.1-43), median overall survival (mOS) was 11.7 months (95% confidence interval [CI], 9.9,15.4). Composite complete remission was achieved in

SUBMITTER: Wolach O 

PROVIDER: S-EPMC11986219 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature