Outcomes for recurrent or metastatic head and neck cancer by HPV status: a systematic review and meta-analysis.

ABSTRACT:

Background

Human papillomavirus (HPV)-positive (HPV+) recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) exhibits distinct clinical behavior compared with HPV-negative (HPV-) R/M HNSCC. However, most studies reference historical efficacy benchmarks from cohorts combining HPV+ and HPV- R/M HNSCC for comparison with the efficacy of novel therapeutics. This analysis aims to assess differential outcomes specific to HPV+ and HPV- R/M HNSCC to reflect HPV-associated prognostic considerations.

Methods

Studies from March 2006 to June 2024 were searched. All therapeutic trials in R/M HNSCC that reported outcomes by HPV status were included. Meta-analyses were conducted to evaluate overall survival (OS) as the primary outcome of interest, objective response rate

SUBMITTER: Park JC 

PROVIDER: S-EPMC11986418 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature