BTLA agonist attenuates Th17-driven inflammation in a mouse model of steroid-resistant asthma.

ABSTRACT:

Introduction

Steroid-resistant asthma does not respond adequately to corticosteroid treatment. The underlying mechanisms driving corticosteroid resistance remain poorly understood, partly due to the absence of suitable animal models. Identifying the immunomodulatory pathways and mechanisms driving steroid resistance is crucial for developing effective therapies.

Methods

In this study, we screened 58 murine strains exposed to house dust mite and identified that the BXD75 strain exhibited neutrophil-skewed, steroid-resistant asthma and elevated Th17 cells. RNA sequencing of lung CD4⁺ T cells from BXD75 was performed to identify immunomodulatory pathways involved in steroid-resistance. The effects of BTLA agonist treatment were assessed on airway hyperreactivity and

SUBMITTER: Quach C 

PROVIDER: S-EPMC11986467 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature