Impact of differentially expressed genes and proteins in donor arterial plaque on renal function recovery following allogeneic kidney transplantation.

ABSTRACT:

Background

Donor kidney arteriosclerotic plaque is a risk factor for renal allograft functional injury. The aim of this study was to screen, identify, and verify differentially expressed genes (DEGs) and proteins in arteriosclerotic plaques and analyze their correlation with renal transplant function recovery.

Methods

This study included 82 deceased donor allogeneic kidney transplant recipients and analyzed 20 eligible donor arterial plaque specimens. Patients were divided into "no or mild" and "moderate or severe" donor arteriosclerotic plaque groups. The latter group was further divided into impaired and normal kidney function groups. Correlations between target DEGs and proteins and transplanted kidney function recovery were determined using immunofluorescence assay, poly

SUBMITTER: Tian Z 

PROVIDER: S-EPMC11986501 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature