Exploring the functional variations of key candidate genes affecting egg production by hypothalamic-pituitary-ovarian axis in chickens.

ABSTRACT: Potential genetic variants associated with chicken egg production traits have been extensively identified, most of which are located in the non-coding regions of the genome. However, which functional variants really drive the egg-laying phenotype change remain elusive. In the present study, by integrating the previously screened egg-laying related candidate genetic variants, transcriptome data derived from 16 high- and low-yield Gushi chickens, and epigenomic analyses, 22 potential functional variants (PFVs) were systematically identified. These PFVs potentially drive the differences in egg production phenotypes by affecting the expression of 10 egg-laying related key candidate genes in the hypothalamus (ZNF804B, DPP10, NEO1 and GABRG1), pituitary (DPP10 and GNG7), and ovary (PHIP, OSTN, G

SUBMITTER: Wang D 

PROVIDER: S-EPMC11986515 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature